避暗實(shí)驗也稱(chēng)被動(dòng)回避實(shí)驗（Passive Avoidance），其基本假設利用了實(shí)驗鼠趨暗的天性。實(shí)驗設備與穿梭實(shí)驗相似，不同之處是兩個(gè)箱體通常設置成一明一暗，而暗室的底柵可以程序性控制給電，動(dòng)物進(jìn)入暗室即受到電擊。反復訓練后，可導致實(shí)驗鼠由趨暗向避暗的轉變，此時(shí)即使暗箱不加電，實(shí)驗鼠也會(huì )有意回避進(jìn)入，形成與天性相反的表現。通過(guò)觀(guān)察并記錄實(shí)驗鼠被動(dòng)回避的潛伏期、錯誤次數等參數可以反映實(shí)驗動(dòng)物的學(xué)習記憶能力。
Gene&I 在十多年的研究與服務(wù)過(guò)程中，積累了豐富的經(jīng)驗，并不斷改進(jìn)產(chǎn)品設計與用戶(hù)體驗，積極探索行為學(xué)的新發(fā)展方向！
Gene&I提供的避暗試驗分析系統，強大之處在于強大的識別能力。由于動(dòng)物在暗室的時(shí)候光線(xiàn)條件不好，很容易出現動(dòng)物無(wú)法追蹤的狀況，而我們獨特的算法杜絕了這一狀況的出現，提供了更精確的試驗參數證。
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Reference
Brachman R A , Lehmann M L , Maric D, et al. Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice[J]. The Journal of Neuroscience, 2015, 35(4): 1530-1538.
Pezzato F A, Can A, Hoshino K, et al. Effect of lithium on behavioral disinhibition induced by electrolytic lesion of the median raphe nucleus[J]. Psychopharmacology, 2014.
Liu X C, Holtze M, Powell S B, et al. Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment–role of brain kynurenic acid[J]. Brain Behavior and Immunity, 2014, 36: 80-89.
Lehmann M L, Brachman R A, Martinowich K, et al. Glucocorticoids Orchestrate Divergent Effects on Mood through Adult Neurogenesis[J]. The Journal of Neuroscience, 2013, 33(7): 2961-2972.
Stein J M, Bergman W, Fang Y, et al. Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin[J]. The Journal of Neuroscience, 2006, 26(8): 2184-2196.